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2) active stage (with energy expenditure) – transfer of iron from the transferrin molecule to cellular structures – mitochondria occurs.
Stages distinguish latent (iron deficiency without anemia) and obvious iron deficiency anemia. According to the severity of modafinil for sale, light (hemoglobin 90–110 g / l), medium (hemoglobin 70–90 g / l) and heavy modafinil uses (hemoglobin below 70 g / l) are isolated.
. The clinic of iron deficiency anemia consists of several symptom complexes, tissue deficiency of iron, snorting modafinil, and an anemic state.
A common symptom is a state of discomfort. Tissue deficiency manifests itself mainly in epithelial tissues as an atrophy process. The skin becomes pale, dry, especially modafinil for sale on the face and hands, flaky, dense, dull. There is a symptom of fragility of hair, they fade, break off at different levels, grow slowly, often fall out. The nails are soft, brittle, stratified, have a fringed edge, dull.
Caries of teeth and their crumbling, loss of luster, modafinil pill enamel roughness is noted. Such people often have atrophic gastritis, achilia, achlorhydria, which in turn increase the deficiency of iron, worsen the process of its absorption. There may be changes in the pelvic organs, disruption of the large intestine, sphincters of the bladder and urethra.
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Sometimes patients have low-grade body temperature and a high susceptibility to infections. Characteristic perversion of taste, smell, can be addicted to the use of chalk, tooth modafinil uk powder, clay, sand, etc.
Often there is a predilection for smells of gasoline, acetone, kerosene modafinil erowid, shoe polish, nail polish. Fatigue, weakness, dizziness, headaches, drowsiness, lack of appetite, palpitations, “flies” before the eyes.
The main hematological indicators are a significant decrease in the amount of hemoglobin and red blood cells, a sharp decrease in the color index (hypochromia associated with a deficiency of hemoglobin in red blood cells), hematocrit. Red blood cells in size become smaller (microcytes), have a different diameter (anisocytosis). Very characteristic of iron deficiency anemia is modafinil for sale; complete modafinil for sale; disappearance of siderocytes from peripheral blood. Osmotic resistance of erythrocytes remains within the normal range of modafinil sleep apnea.
The most characteristic is a drop in the amount of iron in the serum and an increase in the iron binding capacity of transferrin. During the period of exacerbation of the disease, reticulocytosis may not be present or it may be insignificant, but as modafinil amazon treats (correct), the number of reticulocytes is restored.
The stages of the development of the disease are based on laboratory tests.
Regenerative stage: the amount of hemoglobin decreases, and the number of erythrocytes is within the normal range. The color figure is low. The content of leukocytes, platelets – within the normal range. Anisocytosis (microcytosis), erythrocyte hypochromia, slight reticulocytosis are noted. Erythroblastosis is detected (irritation of the red sprout).
Hyporegenerative modafinil for depression stage: reduced hemoglobin and red blood cells. Color indicator in the normal range (0.8–0.9). The content of leukocytes, platelets is somewhat reduced, there is no reticulocytosis. Micro- and macrocytosis (anisocytosis) of erythrocytes, anisochromia (hypo- and hyperchromia). The bone marrow is cellular, but not active, the number of erythroblasts is reduced, they are of various forms (poikilocytosis) and various modafinil star sizes (anisocytosis).
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Hypo- and aplastic anemias
Hypo- and aplastic anemia unite a group of diseases, the main symptom of which is functional insufficiency of the bone marrow. In the genesis of the pathological process is a violation of the proliferation and differentiation of bone marrow cells.
The characteristic signs of this disease of the blood system are complete exhaustion (aplasia) of the bone marrow and a profound violation of its function, which is accompanied by pronounced anemia, leukopenia modafinil tolerance and thrombocytopenia.
There are both quantitative and qualitative differences between hypoplastic and aplastic anemias. With aplastic anemia, a deeper depression of blood formation is noted.